Sep 186 min read

How to Manage Swelling After PRP Injection Face Procedures

Updated: Sep 27

Platelet-rich plasma (PRP) therapy has garnered significant attention in the field of aesthetic medicine, particularly for facial procedures aimed at enhancing skin quality and appearance [1]. PRP therapy involves the use of a patient's own blood, which is processed to concentrate platelets and then injected into the facial tissues. This procedure is known for promoting collagen production, improving skin texture, and offering a natural approach to facial health.

However, one common side effect that patients often experience is swelling after PRP injection face procedures, which, though temporary, can be concerning. This paper provides an in-depth guide for healthcare providers on understanding and managing post-procedure swelling to ensure patient comfort and optimal results.

Understanding Swelling After PRP Facials

Swelling is a typical response following PRP injections, driven by the body's inflammatory reaction to the introduction of concentrated platelets. When platelets are injected into the facial tissues, they release growth factors that stimulate the healing process. This leads to an inflammatory response, characterized by increased blood flow and fluid accumulation in the treated area [3].

The degree of swelling after PRP injection face procedures can vary based on several factors, including the injection technique used, the individual patient's healing response, and the extent of the treated area. It is crucial to emphasize to patients that swelling is a normal part of the healing process and not a sign of complications [4]. Proper management of this swelling is essential for patient comfort and satisfaction.

Managing Swelling After PRP Facials: A Step-by-Step Guide

24–48 Hours After Treatment

Cold Therapy

Applying cold compresses can significantly reduce inflammation and blood flow to the treated area, thereby minimizing swelling. Patients should be advised to apply cold packs for 15–20 minutes every hour during the first 24–48 hours post-procedure. It is important to use a clean cloth to avoid direct contact with the skin, which could cause frostbite.

Elevation

Keeping the head elevated helps promote drainage and reduce fluid retention in the face. Patients should be instructed to sleep with their heads elevated, using extra pillows or a wedge pillow to maintain an inclined position. This can help decrease swelling more rapidly.

Medication

Over-the-counter pain relievers, such as Tylenol, can be recommended to manage discomfort associated with swelling. It is essential to advise patients to consult their healthcare provider before taking any medication to ensure it does not interfere with other treatments or conditions.

Gentle Cleansing

Maintaining cleanliness is crucial, but patients should avoid using harsh products or scrubbing the treated area. A gentle, non-abrasive cleanser should be used, and patients should pat the skin dry with a soft towel.

Maintain a Healthy Diet

A balanced diet can aid in the healing process. Patients should be encouraged to eat nutritious foods that support tissue repair and to stay hydrated. Foods rich in vitamins and minerals can facilitate faster recovery.

48 Hours and Beyond

Gradual Activity

Patients should gradually return to their regular activities, avoiding strenuous exercise or activities that may increase blood flow to the face for the first few days. Light activities can be resumed, but anything that involves heavy lifting or intense physical exertion should be postponed.

Dietary Adjustments

The diet plays a role in managing swelling. Patients should be advised to drink plenty of water to stay hydrated and to avoid salty foods, which can promote fluid retention. Incorporating anti-inflammatory foods like leafy greens, berries, and fatty fish can also be beneficial.

Sun Protection

Protecting the skin from sun exposure is critical after PRP facials. Patients should use a broad-spectrum sunscreen with SPF 30 or higher when going outdoors. Sun protection helps prevent further irritation and supports the healing process.

Sleep and Rest

Adequate sleep is essential for healing. Patients should aim for at least 7–8 hours of sleep per night to support their body's natural recovery processes. Restful sleep can significantly impact the speed and quality of recovery.

When to be Concerned About Post-PRP Swelling

While swelling is typically a normal response, there are specific signs that warrant medical attention. Patients should be educated on these signs and encouraged to contact their healthcare provider if they experience any of the following:

Severe or Prolonged Swelling

If swelling is severe or persists beyond the expected timeframe, it may indicate an abnormal response. Patients should be advised to seek medical evaluation in such cases.

Increased Pain or Redness at the Injection Sites

Pain and redness that intensify rather than diminish over time could signal an infection or other complication. A prompt medical assessment is necessary.

Fever or Chills

The presence of fever or chills may indicate a systemic infection. Patients experiencing these symptoms should contact their healthcare provider immediately.

Drainage or Pus Formation

The appearance of drainage or pus at the injection sites is a clear sign of infection. Immediate medical attention is required to address this issue.

Additional Tips and FAQs

Common Concerns After PRP Facials

Patients often have questions about the recovery process. Addressing these concerns can help alleviate anxiety and ensure adherence to aftercare instructions.

How long does swelling last? Swelling typically peaks within the first 2–3 days and gradually subsides over the following week. Most patients notice significant improvement by days 5–7.
Can I be exposed to the sun? Sun exposure should be minimized, and protective measures such as using sunscreen and wearing hats should be implemented to protect the healing skin.
Is it okay to take a hot shower? Hot showers should be avoided for the first 48 hours, as heat can exacerbate swelling. Lukewarm showers are recommended during this period.

Managing Makeup Application

Patients often wish to know when they can resume makeup use. Makeup can generally be applied after the initial swelling and redness have subsided, typically around days 3–5 post-procedure. It is important to use clean brushes and non-comedogenic products to avoid irritation.

Realistic Expectations for Recovery

Recovery times can vary based on individual factors such as skin type, overall health, and the specific PRP procedure performed. Providing patients with a realistic timeline can help set appropriate expectations and enhance satisfaction with the results.

SELPHYL® Disclaimer

Instructions for the use of SELPHYL® can be found here and here.

SELPHYL® has not been approved by the FDA for subcutaneous, submucous, or intradermal injections in aesthetic medicine, and the safety and effectiveness of SELPHYL® for these conditions have not been established.

SELPHYL® is designed to be used for the safe and rapid preparation of autologous platelet-rich plasma (PRP) from a small sample of peripheral blood at the patient's point of care. The PRP is mixed with autograft and/or allograft bone prior to application to a boney defect to improve handling characteristics.

As of the time of writing, SELPHYL® has no known serious, life-threatening, or fatal risks apart from the adverse reactions described above.

SELPHYL® Limitations, Restrictions, Cautions, and Warnings

Prescription only.
Do not use the kit if the sterile packaging is damaged or compromised.
Follow universal safety precautions for blood collection and sharps disposal.
During blood draw, failure to align and properly seat tubes in the tube holder can result in a loss of vacuum and a loss of blood draw.
During PRP transfer, failure to align and securely seat tubes simultaneously in assembled blood transfer device tube holders can result in a loss of vacuum and the failure of PRP to transfer to the red-top PRFM tube.
Do not initiate the transfer of PRP into the red-top PRFM tube until the physician is ready to complete the procedure.
Do not reuse.

SELPHYL® Contraindications

These are not in FDA-required labeling and are part of SELPHYL®’s clinical evaluation for EU CE requirements.

Direct connection to a patient’s vascular system of circulating blood volume.
Other health conditions and diseases may also contraindicate the use of autologous PRP, including but not limited to low platelet count, sepsis, localized infection in the treatment area, anemia, malignancy with hematologic or bony involvement, and anticoagulation therapy.

Conclusion

In conclusion, while swelling after PRP injection face procedures is a common and temporary side effect, it can be effectively managed with proper aftercare. Healthcare providers play a crucial role in educating patients about the normal course of swelling, providing clear instructions for at-home care, and identifying signs that require medical attention. By following these guidelines, patients can achieve a smooth recovery and enjoy the full benefits of their PRP facial treatment.

For practitioners looking to enhance the effectiveness and safety of PRP treatments, Selphyl® offers a next-generation platelet-rich fibrin (PRF) kit that goes beyond traditional PRP methods. Selphyl’s revolutionary closed-system kits ensure sterility, maximize platelet concentration, and leverage the body’s own biology to promote tissue regeneration and optimal recovery. This innovative technology provides a personalized and minimally invasive solution, designed to integrate seamlessly into clinical workflows and deliver superior clinical outcomes. By using Selphyl®, practitioners can unlock the full potential of PRF to accelerate healing and achieve exceptional results for a wide range of medical specialties.

About the author: Dr. Ali is a medical journalist and copywriter.